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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4G2
All Species:
18.79
Human Site:
T614
Identified Species:
59.05
UniProt:
P78344
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78344
NP_001409.1
907
102362
T614
L
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
Chimpanzee
Pan troglodytes
XP_001170632
1033
115739
T740
L
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
Rhesus Macaque
Macaca mulatta
XP_001093873
1176
131101
T883
L
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
Dog
Lupus familis
XP_851579
701
79569
L455
E
L
V
S
I
S
E
L
A
Q
P
L
E
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62448
906
102087
T613
L
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515837
496
55369
H250
L
G
K
L
D
L
I
H
E
S
I
L
H
K
C
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394628
920
105173
T616
L
E
K
A
D
V
I
T
V
Q
Q
I
H
E
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782944
923
103756
T629
L
K
K
E
G
C
I
T
G
N
N
F
M
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.8
76.9
77.1
N.A.
99.1
N.A.
N.A.
51
N.A.
N.A.
N.A.
N.A.
N.A.
37.9
N.A.
28.9
Protein Similarity:
100
87.8
77.1
77.2
N.A.
99.7
N.A.
N.A.
51.8
N.A.
N.A.
N.A.
N.A.
N.A.
56.7
N.A.
48
P-Site Identity:
100
100
100
0
N.A.
100
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
60
P-Site Similarity:
100
100
100
6.6
N.A.
100
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
40
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
0
0
50
0
13
0
0
0
0
0
63
% A
% Cys:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
13
% C
% Asp:
0
0
0
0
25
0
0
0
0
50
0
0
0
13
0
% D
% Glu:
13
13
0
63
0
0
13
0
13
0
0
0
13
13
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
63
0
0
0
% F
% Gly:
0
13
0
0
63
0
0
0
13
0
0
0
0
0
25
% G
% His:
0
0
0
0
0
0
0
13
0
0
0
0
25
0
0
% H
% Ile:
0
0
0
0
13
50
38
0
0
0
13
13
0
0
0
% I
% Lys:
0
63
38
0
0
0
0
0
0
0
0
0
0
13
0
% K
% Leu:
88
13
0
13
0
13
0
13
0
0
0
25
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
63
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
13
63
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% P
% Gln:
0
0
50
0
0
0
0
0
0
25
13
0
0
50
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
13
0
13
0
0
50
13
0
0
0
13
0
% S
% Thr:
0
0
0
0
0
0
0
75
0
0
0
0
0
0
0
% T
% Val:
0
0
13
0
0
13
0
0
13
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _